منابع مشابه
Vascular and sympathoadrenal responses to bradykinin and a bradykinin analogue.
These experiments were designed to assess the interaction of bradykinin and its antagonist (Arg-Pro-Hyp-Gly-Phe-Ser-DPhe-Phe-Arg-trifluoroacetic acid) with the sympathoadrenal system. Three groups of male Wistar rats received 5-minute intra-arterial infusions of either dextrose (Group 1, n = 6), bradykinin, 250 micrograms/min (Group 2, n = 5), or bradykinin, 25 micrograms/min (Group 3, n = 4). ...
متن کاملVasodepressor role of endogenous bradykinin assessed by a bradykinin antagonist.
This study was designed to examine the contribution of bradykinin to the depressor effect of different antihypertensive drugs in two-kidney renovascular hypertensive rats, using a new specific antagonist of bradykinin. First, the inhibitory capacity of this peptide for exogenously injected bradykinin (75-200 ng) was tested. An inhibition of the vasodepressor action of bradykinin by over 50% was...
متن کاملIntracoronary and Epicardial Bradykinin
Background. Stimulation of left ventricular (LV) receptors with sympathetic afferents generally results in reflex sympathoexcitatory responses. Stimulation of LV receptors with vagal afferents results in reflex sympathoinhibitory responses. Vagal afferents are known to be preferentially distributed to the inferoposterior (IP) wall of the LV. We tested the hypothesis that there is also a prefere...
متن کاملBradykinin in carcinoid syndrome.
Bradykinin concentrations in peripheral venous blood were measured in seven patients with carcinoid syndrome. The diagnosis was based on typical symptoms and raised urinary excretion of 5-hydroxy-3-indole acetic acid; the carcinoid tumour was verified histologically. Two patients were flushing constantly and the other patients had flushing attacks two to 10 times daily. Several blood samples we...
متن کاملAction of Bradykinin
BRADYKININ acts as a powerful vasodilator upon the systemic circulation.'-10 Contradictory reports, however, have been published concerning its effect on the pulmonary vascular bed. In different studies carried out in various animal species, the drug has been reported as eliciting either dilatation7' 11 or constriction12 of the pulmonary vessels. Gersmeyer and Spitzbarth6 observed a rise in pul...
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ژورنال
عنوان ژورنال: BMJ
سال: 1966
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.1.5492.923-b